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CD62L Antibody [DREG-56]

CATALOG NUMBER: 76-212

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The DREG-56 monoclonal antibody specifically reacts with human CD62L, also known as L-selectin and LECAM-1.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
SELL
Additional Names:
TQ1, LAM1, LEU8, LNHR, LSEL, CD62L, LYAM1, PLNHR, LECAM1, SELL
Ncbi Gene Id Number:
6402
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The DREG-56 monoclonal antibody specifically reacts with human CD62L, also known as L-selectin and LECAM-1. It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules). CD62L is expressed on monocytes, NK cells, neutrophils, granulocytes, and subsets of T and B cells. It is reported that the DREG-56 antibody inhibits the binding of lymphocytes to HEV tissue in frozen peripheral tissue.
Background Reference 1:
Schlossman, S. F. (1995).Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 2:
Kishimoto, T. K., Jutila, M. A., Butcher, E. C. (1990). Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule.Proceedings of the National Academy of Sciences,87(6), 2244-2248.
Background Reference 3:
Kishimoto, T. K., Warnock, R. A., Jutila, M. A., Butcher, E. C., Lane, C., Anderson, D. C., Smith, C. W. (1991). Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro.Blood,78(3), 805-811.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-212

List Size:
0.5 mg

List Price:

$585.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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