CD73 Antibody [AD2] (APC)

CATALOG NUMBER: 76-312

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
APC
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
APC
Tested Applications:
Flow
Specificity:
The AD2 monoclonal antibody specifically reacts with human CD73 (ecto-5’-nucleotidase), a 70 kDA glycosyl phosphatidylinositol (GPI)-anchored glycoprotein.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
NT5E
Additional Names:
NT, eN, NT5, NTE, eNT, CD73, E5NT, CALJA, NT5E
Ncbi Gene Id Number:
4907
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The AD2 monoclonal antibody specifically reacts with human CD73 (ecto-5’-nucleotidase), a 70 kDA glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 catalyzes the dephosphorylation of adenosine monophosphate (AMP) to adenosine and is expressed on subsets of B, T, dendritic, endothelial, and mesenchymal stem cells. It is also involved in the adhesion of lymphocytes to endothelium and T cell activation.
Background Reference 1:
Schlossman, S. F. (1995).Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 2:
Nakamura, T., Kubagawa, H., Ohno, T., Cooper, M. D. (1993). Characterization of an IgM Fc-binding receptor on human T cells.The Journal of Immunology,151(12), 6933-6941.
Background Reference 3:
Alam, M. S., Kurtz, C. C., Rowlett, R. M., Reuter, B. K., Wiznerowicz, E., Das, S., ... Ernst, P. B. (2009). CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice.Journal of Infectious Diseases,199(4), 494-504.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-312

List Size:
25 tests

List Price:

$302.00

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