CD14 Antibody [Sa2-8] (FITC)

CATALOG NUMBER: 76-395

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
FITC
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
FITC
Tested Applications:
Flow
Specificity:
The Sa2-8 monoclonal antibody specifically reacts with mouse CD14, a cell surface anchored glycoprotein that is primarily expressed on macrophages and is secreted in certain conditions.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2a, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
CD14
Additional Names:
CD14, CD14
Ncbi Gene Id Number:
929
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The Sa2-8 monoclonal antibody specifically reacts with mouse CD14, a cell surface anchored glycoprotein that is primarily expressed on macrophages and is secreted in certain conditions. CD14 associates with LPS and LBP to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The Sa2-8 antibody exhibits a weak antagonistic activate in relation to TNF alpha production and NF-kappa B activation.
Background Reference 1:
Akashi, S., Saitoh, S. I., Wakabayashi, Y., Kikuchi, T., Takamura, N., Nagai, Y., ... Miyake, K. (2003). Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2 Higher Affinity than That with MD-2 or CD14.The Journal of experimental medicine,198(7), 1035-1042.
Background Reference 2:
Oliva, C., Turnbough, C. L., Kearney, J. F. (2009). CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages.Proceedings of the National Academy of Sciences,106(33), 13957-13962.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-395

List Size:
0.1 mg

List Price:

$365.00

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