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CD8b Antibody [341]

CATALOG NUMBER: 76-659

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Mouse
Species Reactivity:
Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Rat
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The 341 monoclonal antibody specifically reacts with the beta chain of the Rat CD8 molecule.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
Cd8b
Additional Names:
Cd8b1, Cd8b
Ncbi Gene Id Number:
24931
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 341 monoclonal antibody specifically reacts with the beta chain of the Rat CD8 molecule. The alpha and beta chains of the CD8 molecule form a heterodimer common on most thymocytes. The CD8 positive T cells of athymic rats and most NK cells express a homodimer composed solely of CD8a. It is reported that macrophages express CD8 alpha and beta chains for signal transduction. CD8 is an antigen co-receptor that interacts with MHC class I molecules on antigen-presenting cells.
Background Reference 1:
Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., ... Terhorst, C. (1998). The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.Nature,395(6701), 462-469.
Background Reference 2:
Thomas, Y., Sosman, J., Irigoyen, O., Friedman, S. M., Kung, P. C., Goldstein, G., Chess, L. (1980). Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative TT interactions in the immunoregulation of B cell differentiation.The Journal of Immunology,125(6), 2402-2408.
Background Reference 3:
Campanelli, R., Palermo, B., Garbelli, S., Mantovani, S., Lucchi, P., Necker, A., ... Giachino, C. (2002). Human CD8 coreceptor is strictly involved in MHCpeptide tetramerTCR binding and T cell activation.International immunology,14(1), 39-44.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-659

List Size:
0.5 mg

List Price:

$494.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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