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CD28 Antibody [37.51]

CATALOG NUMBER: 76-739

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, IP
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays, IP
Specificity:
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Golden Syrian Hamster IgG
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Cd28
Additional Names:
CH29-189K17.3, Cd28
Ncbi Gene Id Number:
12487
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes.The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.
Background Reference 1:
Nandi, D., Gross, J. A., Allison, J. P. (1994). CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells.The Journal of Immunology,152(7), 3361-3369.
Background Reference 2:
Gross, J. A., Callas, E. L. E. N. I., Allison, J. P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse.The Journal of Immunology,149(2), 380-388.
Background Reference 3:
Grossi, J. A., Raulet, D. H., Allison, J. P. (1992). CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.Nature,356, 607-9.
Background Reference 4:
Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., Podack, E. R. (1996). CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis.The Journal of Immunology,157(10), 4347-4353.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-739

List Size:
0.5 mg

List Price:

$365.00

Datasheet
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