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CD127 Antibody [A7R34] (APC)

CATALOG NUMBER: 76-922

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
APC
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
APC
Tested Applications:
Flow
Specificity:
The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2a, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Il7r
Additional Names:
CD127, IL-7Ralpha, Il7r
Ncbi Gene Id Number:
16197
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127. 
Background Reference 1:
Vudattu, N. K., Magalhaes, I., Schmidt, M., Seyfert-Margolis, V., Maeurer, M. J. (2007). Reduced numbers of IL-7 receptor (CD127) expressing immune cells and IL-7-signaling defects in peripheral blood from patients with breast cancer. International journal of cancer,121(7), 1512-1519.
Background Reference 2:
Pandrau-Garcia, D., de Saint-Vis, B., Saeland, S., Renard, N., Ho, S., Moreau, I., ... Galizzi, J. P. (1994). Growth inhibitory and agonistic signals of interleukin-7 (IL-7) can be mediated through the CDw127 IL-7 receptor.Blood,83(12), 3613-3619.
Background Reference 3:
van Roon, J. A., Hartgring, S. A., van der Wurff-Jacobs, K. M., Bijlsma, J. W., Lafeber, F. P. (2010). Numbers of CD25+ Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients.Rheumatology,49(11), 2084-2089.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-922

List Size:
0.025 mg

List Price:

$217.00

Datasheet
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