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Western blot of rat cortex lysate showing specific labeling of the ~25k SNAP25 protein.
Western blot of rat cortex lysate showing specific labeling of the ~25k SNAP25 protein.

SNAP25 Antibody

CATALOG NUMBER: 50-190

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Bovine, Chicken, Dog, Goat, Human, Mouse, Rat, Zebrafish
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Bovine, Chicken, Dog, Goat, Human, Mouse, Rat, Zebrafish
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat SNAP25 conjugated to keyhole limpet hemocyanin (KLH).
Conjugate:
Unconjugated
Tested Applications:
WB
Predicted Molecular Weight:
25
Purification:
Affinity Purified
Clonality:
Polyclonal
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
SNAP25 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Snap25
Protein Accession Number:
P60881
Protein Gi Number:
46397720
Ncbi Gene Id Number:
25012
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer’s Disease (Greber et al.,1999). In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia (Fatemi et al., 2001).
Background Reference 1:
Fatemi SH, Sidwell R, Kist D, Akhter P, Meltzer HY, Bailey K, Thuras P, Sedgwick J (1998) Differential expression of synaptosome-associated protein 25 kDa (Snap25) in hippocampi of neonatal mice following exposure to human influenza virus in utero. Brain Res 800(1):1-9..
Background Reference 2:
Greber S, Cairns N, Lubec G, Fountoulakis M (1999) Decreased levels of the synaptosomal associated protein 25 in the brains of patients with Down Syndrome and Alzheimer’s Disease. Electrophoresis 20 (4-5):928-34.
Background Reference 3:
Ando K, Kudo Y, Takahashi M (2005) Negative regulation of neurotransmitter release by calpain: a possible specific involvement of Snap25 cleavage. J Neurochem 94(3):651-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-190

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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