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Western blot of rat cortex lysate showing specific labeling of the ~15 k alpha synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide (peptide) used asantigen but not by the corresponding dephosphopeptide (not shown).
Western blot of rat cortex lysate showing specific labeling of the ~15 k alpha synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide (peptide) used asantigen but not by the corresponding dephosphopeptide (not shown).

Alpha synuclein (phospho Ser129) Antibody

CATALOG NUMBER: 50-241

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Bovine, Dog, Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Bovine, Dog, Human, Mouse, Rat
Immunogen:
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha synuclein.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, human, mouse, and non-human primate based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Predicted Molecular Weight:
15
Purification:
Affinity Purified
Clonality:
Polyclonal
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
Alpha synuclein antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Snca
Protein Accession Number:
P37377
Protein Gi Number:
586065
Ncbi Gene Id Number:
29219
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).
Background Reference 1:
Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein. J Biol Chem Jan 7;275(1): 390-7.
Background Reference 2:
Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C (2002) Misfolded proteinase k resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha synucleinopathies. J Clin Invest Nov; 110(10):1403-5.
Background Reference 3:
Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA (2005) Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y Cells. J Neurosci June 8; 25(23):5544-5552.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-241

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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