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Tyrosine Hydroxylase (Phospho-Ser31) Antibody
Tyrosine Hydroxylase (Phospho-Ser31) Antibody

Tyrosine Hydroxylase (phospho Ser31) Antibody

CATALOG NUMBER: XPS-1032

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Immunogen:
TH (Ser31) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho-Ser31 of rat tyrosine hydroxylase (TH).
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Application Note:
Applications include Dot Blots (DB), Immunoblotting (IB), Immunofluorescence (IF), Immunohistochemistry (IHC) and Western Blots (WB). Mouse and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. When internally tested under ideal conditions the working dilutions were 1:1000 for IF, IHC, DB and WB.
Specificity:
Tyrosine Hydroxylase antibody is specific for the 60k Tyrosine Hydroxylase phosphorylated at Ser31 in PC-12 cells stimulated by Okadaic Acid.
Predicted Molecular Weight:
60
Purification:
Affinity Purified
Clonality:
Polyclonal
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
For long term storage –80°C is recommended, but shorter term storage at –20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Ncbi Official Symbol:
Th
Protein Accession Number:
P04177
Protein Gi Number:
136577
Ncbi Gene Id Number:
25085
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons. We raised this polyclonal antibody against a peptide representing the sequence around Ser19 in rat TH purified. This antibody is suitable for most immunochemical applications in a variety of mammalian and some non-mammalian species.
Background Reference 1:
Witkovsky, P., Gabriel, R., Haycock, J. W., and Meller, E., "Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina," J. Chem. Neuroanat., 19 (2000) 105 - 116.
Background Reference 2:
Salvatore, M.F., Garcia-Espana, A., Goldstein, M., Deutch, A.Y., and Haycock, J.W., "Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds," J. Neurochem., 75 (2000) 225 - 232.
Background Reference 3:
Xu, Z.-Q., Lew, J. Y., Harada, K., Aman, K., Goldstein, M., Deutch, A., Haycock, J. W., and Hokfelt, T., "Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies," Neuroscience, 82 (1998) 727-738.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

XPS-1032

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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