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Western blot analysis of lysed extracts from 293 and THP1 cells using IκB-α (Ab-42).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkappaB-α (Ab-42).
Western blot analysis of lysed extracts from 293 and THP1 cells using IκB-α (Ab-42).

IkB a (Ab 42) Antibody

CATALOG NUMBER: 79-350

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
IkB-a (Ab-42) antibody was raised against a peptide sequence around aa. 40~44 (E-E-Y-E-Q) derived from Human IkappaB-α.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
This antibody detects endogenous level of total IkappaB-α protein.
Predicted Molecular Weight:
39 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
NFKBIA
Additional Names:
IKBA, MAD-3, NFKBI, BSP1, MADH1, MADR1, I-kappa-B-alpha, IKBA, NF-kappaB inhibitor alpha, NFKBIA
Protein Accession Number:
NP_065390.1
Protein Gi Number:
10092619
Ncbi Gene Id Number:
4792
Background:
Inhibits the activity of dimeric NF-κ-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Background Reference 1:
Beraud C, et al. (1999) Proc Natl Acad Sci U S A 96 (2): 429-434. Sundstrom S, et al. (2005) J Virol 79 (4): 2230-2239. Liu L, et al. (1998) Mol Cell Biol 18 (7): 4221-4234. Shrivastava A, et al. (1998) J Virol 72 (12): 9722-9728. Franzoso G, et al. (1997) Genes Dev 11 (24): 3482-3496.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-350

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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