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Immunofluorescence staining of methanol-fixed HeLa cells using Tyrosine Hydroxylase (Phospho-Ser40).
Immunofluorescence staining of methanol-fixed HeLa cells using Tyrosine Hydroxylase (Phospho-Ser40).

Tyrosine Hydroxylase (phospho Ser40) Antibody

CATALOG NUMBER: 79-474

Clonality:
Polyclonal
Tested Applications:
IF
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Tyrosine Hydroxylase (Phospho-Ser40) antibody was raised against a peptide sequence around phosphorylation site of serine 40 (R-Q-S (p) -L-I) derived from Human Tyrosine Hydroxylase (TH).
Conjugate:
Unconjugated
Tested Applications:
IF
Application Note:
Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of TyrosineHydroxylase only when phosphorylated at serine 40.
Predicted Molecular Weight:
55 - 60 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
TH
Additional Names:
TYH, DYT14, DYT5b, MAPTL, MTBT1, TAU, TY3H, TYH, Tyrosine 3-hydroxylase, tyrosine hydroxylase
Protein Accession Number:
NP_000351.2
Protein Gi Number:
88900503
Ncbi Gene Id Number:
7054
Background:
The protein encoded by Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Background Reference 1:
Vazin T, et al. Stem Cells. 2008 Jun;26 (6): 1517-25Pistocchi A, et al. BMC Dev Biol. 2008 Mar 10;8:27 Fukakusa A, et al. J Pharmacol Sci. 2008 Feb;106 (2): 321-4.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-474

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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