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Trk A (phospho Tyr757) Antibody

CATALOG NUMBER: 79-868

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
Trk A (phospho Tyr757) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y (p)-A-I) derived from Human Trk A.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757.
Predicted Molecular Weight:
87 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
NTRK1
Additional Names:
TRKA, TRK, NTRK1, p140-TrkA
Protein Accession Number:
NP_002520.2
Protein Gi Number:
94730402
Ncbi Gene Id Number:
4914
Background:
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Background Reference 1:
Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989).
Background Reference 2:
Shelton D.L., J. Neurosci. 15:477-491(1995).
Background Reference 3:
The MGC Project Team, Genome Res. 14:2121-2127(2004).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-868

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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