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Western blot analysis of extracts from 293 cells (Lane 2), using BRCA1 (Phospho-Ser1457) Antibody. The lane on the left is treated with antigen-specific peptide.
Western blot analysis of extracts from 293 cells (Lane 2), using BRCA1 (Phospho-Ser1457) Antibody. The lane on the left is treated with antigen-specific peptide.

BRCA1 (phospho Ser1457) Antibody

CATALOG NUMBER: 79-897

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
BRCA1 (phospho Ser1457) antibody was raised against a peptide sequence around phosphorylation site of Serine 1457 (L-T-S (p)-Q-K) derived from Human BRCA1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 1457.
Predicted Molecular Weight:
220 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
BRCA1
Additional Names:
BRCA1, Breast cancer type 1 susceptibility protein, familial breast/ovarian cancer gene 1
Protein Accession Number:
NP_009225.1
Protein Gi Number:
6552299
Ncbi Gene Id Number:
672
Background:
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation
Background Reference 1:
Miki Y., Science 266:66-71(1994).
Background Reference 2:
Smith T.M., Genome Res. 6:1029-1049(1996).
Background Reference 3:
Wilson C.A., Oncogene 14:1-16(1997).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-897

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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