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Frozen section of lamina fibrosa from porcine aortic valve leaflet subjected to bicuspid aortic value wall shear stress was stained with Rat Anti-Mouse CD54-UNLB (Cat. No. 98-812) followed by a secondary antibody and DAPI.Image from Sun L, Chandra S, Sucosky P. Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease. PLoS One. 2012;7(10):e48843. Figure 5
BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD54-UNLB (Cat. No. 98-812) followed by Mouse Anti-Rat IgG2b-CY5 .
Frozen section of lamina fibrosa from porcine aortic valve leaflet subjected to bicuspid aortic value wall shear stress was stained with Rat Anti-Mouse CD54-UNLB (Cat. No. 98-812) followed by a secondary antibody and DAPI.Image from Sun L, Chandra S, Sucosky P. Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease. PLoS One. 2012;7(10):e48843. Figure 5

CD54 Antibody [YN1/1.7.4]

CATALOG NUMBER: 98-812

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse, Pig
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Mouse, Pig
Conjugate:
Unconjugated
Tested Applications:
Flow
Application Note:
CD54 Antibody [YN1/1.7.4] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, blocking, and purification assays.
Specificity:
CD54
Clonality:
Monoclonal
Isotype:
IgG2b
Physical State:
Liquid
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Storage Conditions:
Store vial at 2-8°C
Ncbi Official Symbol:
Icam1
Additional Names:
ICAM-1, Ly-47
Protein Accession Number:
P13597
Ncbi Gene Id Number:
15894
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN gamma, IL-1, TNF-alpha, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

98-812

List Size:
0.5 mg

List Price:

$365.00

Datasheet
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