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PDL1 Detection Set

CATALOG NUMBER: SD8500

Clonality:
Monoclonal
Tested Applications:
ELISA, Flow, ICC, IF
Host Species:
Llama
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Llama
Species Reactivity:
Human
Immunogen:
PD-L1 antibodies were raised against a recombinant protein corresponding to amino acids 19 - 239 of human PD-L1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, Flow, ICC, IF
Set Contents:
20 μg:
PD-L1 Antibody [F6A9], Cat. No. SD8639
PD-L1 Antibody [F2G2], Cat. No. SD8641

100 μg:
cMyc-tag Antibody [5G5H7], Cat. No. PM-7669
Purification:
PD-L1 Antibodies are affinity chromatography purified via Nickel column.Antibodies are supplied as a His-tagged purified protein.  They also contains a myc-tag for detection.
Clonality:
Monoclonal
Isotype:
sdab
physical-state:
Liquid
Buffer:
PBS containing 0.02% sodium azide.
Concentration:
Antibody 1 mg/mL
Storage Conditions:
PD-L1 antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
User Note:
Optimal dilutions for each application to be determined by the researcher. Antibodies have a C-terminal HIS 6-Tag followed by a myc-Tag for detection and have been tested using ProSci's PM-7669 (cMyc-tag Antibody [5G5H7]).
Background:
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.
Background Reference 1:
Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.
Background Reference 2:
Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.
Background Reference 3:
LaGier J and Pober JS. Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1). Hum. Immunol. 2006; 67:568-78.
Set Contents:
20 μg:
PD-L1 Antibody [F6A9], Cat. No. SD8639
PD-L1 Antibody [F2G2], Cat. No. SD8641

100 μg:
cMyc-tag Antibody [5G5H7], Cat. No. PM-7669

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

SD8500

List Size:
1 Set

List Price:

$259.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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