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Recombinant Human IL-17A/CTLA-8 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Immobilized Recombinant human IL17RA , His Tag at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A,The EC<sub>50</sub> of human IL-17A is 32.5-130 ng/mL.
Recombinant Human IL-17A induce IL-6 secretion by Hela cells. The ED<sub>50</sub> for this effect is 2.64-10.58 ng/mL, corresponding to a specific activity of 9.45×10<sup>4</sup>~3.79×10<sup>5</sup> units/mg.
Recombinant Human IL-17A/CTLA-8 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human IL-17A/CTLA-8 Recombinant Protein (84-993)

CATALOG NUMBER: 84-993

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ile20-Ala155
Fusion Tag:
C-His
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
16.37 kDa
Biological Activity:
1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant human IL17RA at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A, the EC50 of human IL-17A is 32.5-130 ng/mL.
2.Measured by its ability to induce IL-6 secretion by Hela cells. The ED50 for this effect is 2.64-10.58 ng/mL, corresponding to a specific activity of 9.45×104~3.79×105 units/mg.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 0.1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
IL17A, CTLA-8, CTLA8, IL-17, IL-17A, IL17, interleukin-17A,CTLA-8,CTLA8,IL-17,IL-17A,IL17
Protein Accession Number:
NP_002181.1
Ncbi Gene Id Number:
3605
Background:
IL17, also known as IL17a and CTLA8, is a is a 15-20 kDa glycosylated cytokine which belongs to the IL-17 family. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL17A promotes protective mucosal and epidermal inflammation in response to microbial infection .It induces chemokine production, neutrophil influx, and the production of antibacterial peptides .IL17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF alpha induced shock . In contrast, it can protect against the progression of colitis by limiting chronic inflammation . IL17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity .

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

84-993

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $126.00 through $280.00

Datasheet
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