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Recombinant Human/Mouse/Rat mature TGF-beta 3 Protein was determined by SDS-PAGE under reducing (R) and non-reducing (NR) conditions.
Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. The ED<sub>50</sub> for this effect is 24.2-96.6 pg/mL, corresponding to a specific activity of 1.04×10<sup>7</sup>~4.17×10<sup>7</sup> units/mg.
Recombinant Human/Mouse/Rat mature TGF-beta 3 Protein enhances α-SMA and BMP7 expression in NRK-49F rat kidney cells.0.5-5ng/mL of Recombinant Human/Mouse/Rat mature TGF-beta 3 can effectively enhance α-SMA and BMP7 expression.
Recombinant Human/Mouse/Rat mature TGF-beta 3 Protein was determined by SDS-PAGE under reducing (R) and non-reducing (NR) conditions.

Human/Mouse/Rat mature TGF-beta 3 Recombinant Protein (85-107)

CATALOG NUMBER: 85-107

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ala301-Ser412(Tyr340Phe)
Fusion Tag:
No tag
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
12.70 kDa
Biological Activity:
Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 24.2-96.6 pg/mL, corresponding to a specific activity of 1.04×107~4.17×107 units/mg.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5. Contact us for customized product form or formulation.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
TGFB3,ARVD,ARVD1,LDS5,RNHF,TGF-beta3
Protein Accession Number:
P10600
Ncbi Gene Id Number:
7043
Background:
Transforming growth factor beta 3(TGFB3) is a member of a TGF - β superfamily which is defined bytheirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form ofTGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subsetofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involvedincell differentiation, embryogenesis and development.It is believed to regulate molecules involved incellularadhesion and extracellular matrix (ECM) formation during the process of palate development. WithoutTGF-β3,mammals develop a deformity known as a cleft palate.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-107

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $210.00 through $490.00

Datasheet
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