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Recombinant Human CXCL12/SDF-1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Recombinant Human CXCL12/SDF-1 Protein chemoattract MOLT4 cells. The ED<sub>50</sub> for this effect is 11.47-45.86 ng/mL, corresponding to a specific activity of 2.18×10<sup>4 </sup>~8.72×10<sup>4</sup> units/mg.
Recombinant Human CXCL12/SDF-1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human CXCL12/SDF-1 Recombinant Protein (85-669)

CATALOG NUMBER: 85-669

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
Pichia
Species:
Human
source-species:
Pichia
Recombinant Protein Sequence:
Lys22-Lys89
Fusion Tag:
NO-tag
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
7.96 kDa
Biological Activity:
Measured by its ability to chemoattract MOLT4 cells. The ED50 for this effect is 11.47-45.86 ng/mL, corresponding to a specific activity of 2.18×104 ~8.72×104 units/mg.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 0.1 EU/μg of the protein by LAL method.
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12;CXCL12
Protein Accession Number:
NP_954637.1.
Ncbi Gene Id Number:
6387
Background:
Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-669

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $140.00 through $350.00

Datasheet
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