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Recombinant Human IFN-alpha 21 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
Recombinant Human IFN-alpha 21/IFNA21 Protein cytotoxicity assay using TF-1 cells. The ED<sub>50</sub> for this effect is 0.50-1.98 ng/mL, corresponding to a specific activity of 5.05×10<sup>5</sup>~2.00×10<sup>6</sup> units/mg.
Recombinant Human IFN-alpha 21 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Human IFN-alpha 21 Recombinant Protein (85-885)

CATALOG NUMBER: 85-885

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Cys24-Glu189
Fusion Tag:
C-His
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
20.15 kDa
Biological Activity:
Measured in a cell cytotoxicity assay using TF-1 cells. The ED50 for this effect is 0.50-1.98 ng/mL, corresponding to a specific activity of 5.05×105~2.00×106 units/mg.
Purity:
≥ 90% as determined by SDS-PAGE.
Endotoxin:
< 0.01 EU/μg of the protein by LAL method
physical-state:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
IFNA21; IFN-alpha 21; IFNalpha F; IFN-alpha F; IFN-alpha-21; IFN-alphaI; interferon alpha-21; Interferon alpha-F; interferon, alpha 21; LeIF F; leukocyte interferon protein; MGC126687; MGC126689
Protein Accession Number:
NP_002166.2
Ncbi Gene Id Number:
3452
Background:
Interferons (IFN) are a family of cytokines with potent antiviral, anti-proliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors. Human IFNA2 was originally cloned in the early '80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology . Structurally, type I IFNs belong to the class of five helical_x001E_bundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds . There is not a mouse homolog for IFNA21, but mature human IFNA21 is identical to chimpanzee IFNA21. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit) . Individual IFNA subtypes are known to display unique efficacies to viral protection, with IFNA21 displaying intermediate activity inducing interferon stimulating genes. Further, human IFNA21 has shown weak anti-viral activity against viruses such as metapneumovirus .

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-885

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $140.00 through $350.00

Datasheet
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