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Recombinant Human Mature BMP-7 Protein was determined by SDS-PAGE under reducing (R) and non-reducing (NR) conditions.
Recombinant Human Mature BMP-7 Protein induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.The ED<sub>50</sub> for this effect is 34.9-139.58 ng/mL, corresponding to a specific activity of 7.2×10<sup>3</sup>~2.87×10<sup>4</sup> units/mg.
Recombinant Human Mature BMP-7 Protein was determined by SDS-PAGE under reducing (R) and non-reducing (NR) conditions.

Human Mature BMP-7 Recombinant Protein (85-990)

CATALOG NUMBER: 85-990

Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Specifications
Source Species:
HEK293 cells
Species:
Human
Source Species:
HEK293 cells
Recombinant Protein Sequence:
Ser293-His431
Fusion Tag:
No-Tag
Tested Applications:
Bioactivity Test, ELISA, Immunogen, SDS-PAGE, WB
Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Predicted Molecular Weight:
15.68 kDa
Biological Activity:
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.The ED50 for this effect is 34.9-139.58 ng/mL, corresponding to a specific activity of 7.2×103~2.87×104 units/mg.
Purity:
≥ 95 % as determined by SDS-PAGE.
Endotoxin:
< 0.1 EU/μg of the protein by LAL method.
Physical State:
Lyophilized
Buffer:
Lyophilized from a 0.22 μm filtered solution of 50mM acetic acid, pH3.6.
Storage Conditions:
Store at -20°C.Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Additional Names:
BMP7, OP1,Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, Eptotermin alfa
Protein Accession Number:
NP_001710.1
Ncbi Gene Id Number:
655
Background:
BMP-7 (Bone morphogenetic protein 7) is a bone morphogenetic protein which belongs to the TGF-β superfamily. OP-1 is expressed in the brain, kidneys, and bladder. BMP-7 may be involved in bone homeostasis and plays a key role in the transformation of mesenchymal cells into bone and cartilage. The phosphorylation of SMAD1 and SMAD5 can be induced by BMP-7, which in turn induce transcription of numerous osteogenic genes. BMP-7 treatment can also induce all of the genetic markers of osteoblast differentiation in many cell types. Human recombinant BMP-7 protein can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma. It also functions in the treatment of tibial non-union, frequently in cases where a bone graft has failed. It is found that BMP7 has the potential for treatment of chronic kidney disease.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

85-990

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $252.00 through $630.00

Datasheet
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