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Western blot analysis in HepG2 cell line lysates (35ug/lane).
ADRA2C Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in HepG2 cell line lysates (35ug/lane).

ADRA2C Antibody

CATALOG NUMBER: 57-834

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This ADRA2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-382 amino acids from the C-terminal region of human ADRA2C.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
50 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ADRA2C
Additional Names:
Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR, ADRA2C, ADRA2L2, ADRA2RL2
Protein Accession Number:
P18825
Protein Gi Number:
20141211
Ncbi Gene Id Number:
152
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Alpha-2-adrenergic receptors are members of the Gprotein-coupled receptor superfamily. They include 3 highlyhomologous subtypes: alpha2A, alpha2B, and alpha2C. These receptorshave a critical role in regulating neurotransmitter release fromsympathetic nerves and from adrenergic neurons in the centralnervous system. The mouse studies revealed that both the alpha2Aand alpha2C subtypes were required for normal presynaptic controlof transmitter release from sympathetic nerves in the heart andfrom central noradrenergic neurons. The alpha2A subtype inhibitedtransmitter release at high stimulation frequencies, whereas thealpha2C subtype modulated neurotransmission at lower levels ofnerve activity. This gene encodes the alpha2C subtype, whichcontains no introns in either its coding or untranslated sequences.
Background Reference 1:
Chen, Q.J., et al. Clin. Biochem. 43(15):1201-1204(2010)
Background Reference 2:
Maqbool, A., et al. J. Hypertens. 28(10):2084-2093(2010)
Background Reference 3:
Saus, E., et al.Psychiatr Res 44(14):971-978(2010)
Background Reference 4:
Gao, Y., et al. Ophthalmology (2010) In press :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-834

List Size:
400 ul

List Price:

$495.00

Datasheet
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