Glycan-Specific antibodies are a popular detection tool, diagnostic reagent, and therapeutic agent due to glycosylation occurring on characteristic and disease state-specific markers. For example, HIV-1 vaccine research has interest in targeting highly glycosylated protein gp120 for inactivating the virus envelope. Challenge: Developing antibodies against post-translationally modified glycan sugar residues presents many challenges such as low […]
Developing antibodies to membrane spanning targets such as ion channels and GPCR family members Background: G-protein-coupled receptors (GPCRs) and ion channels are instrumental players in many signaling transduction pathways, making them the largest class of targets for therapeutics and drug discovery. There are over 350 non-olfactory GPCRs that are the receptors for a very diverse […]
Detecting HIV early is essential in providing in optimal patient care. p24 is a component of the HIV capsule which is secreted in high levels in the blood during early stages of HIV-1 infection. As such, it can be used for early detection of the disease. In order to develop an immunoassay to detect p24 […]
Antivenom is an antibody product that neutralizes a particular venom’s toxins. Venoms contain a complex mixture of hundreds of substances. Typically, an animal, such as a horse or goat, is injected with a small amount of venom. The antibodies released by the animal’s immune system are then harvested through blood collection. The blood serum or […]
Antibodies against small molecule haptens enable robust and rapid detection, monitoring and quantification using assays such as ELISA or IHC/IF. Challenge: Small molecules are notoriously difficult to illicit an immune response against due to their small size. Small molecule immunogenicity can be improved with conjugation to a carrier protein; however, there can be challenges in […]
