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Western blot analysis of lysed extracts from 293 cells using IRS-1 (Ab-636).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IRS-1 (Ab-636).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using IRS-1 (Ab-636).
Western blot analysis of lysed extracts from 293 cells using IRS-1 (Ab-636).

IRS 1 (Ab 636) Antibody

CATALOG NUMBER: 79-372

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
IRS-1 (Ab-636) antibody was raised against a peptide sequence around aa.634~638 (P-M-S-P-K) derived from Human IRS-1.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of total IRS-1 protein.
Predicted Molecular Weight:
180 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
IRS1
Additional Names:
HIRS-1, BHLHB26, IRS-1, IRS1
Protein Accession Number:
NP_005535.1
Protein Gi Number:
5031805
Ncbi Gene Id Number:
3667
Background:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
Background Reference 1:
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1): 63-76Kadowaki T, et al. (2000) J Clin Invest; 106 (4): 459-465Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97 (5): 2355-2360

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-372

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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