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Western blot analysis using MYST1 monoclonal antibody against truncated MYST1 - His recombinant protein
Immunohistochemical analysis of paraffin - embedded human rectum adenocarcinoma (top) and breast infiltrating carcinoma (bottom) showing nuclear location using Hmof / MYST1 antibody with DAB staining.
Western blot analysis using MYST1 monoclonal antibody against truncated MYST1 - His recombinant protein

MYST1 Antibody [8C4C4]

CATALOG NUMBER: 32-197

Clonality:
Monoclonal
Tested Applications:
ELISA, WB
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Immunogen:
Ni-NTA purified truncated recombinant MYST1-trx expressed in E. Coli strain BL21 (DE3).
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
Western Blot:1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Clonality:
Monoclonal
Isotype:
IgG2b
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Storage Conditions:
MYST1 monoclonal antibody can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
KAT8
Additional Names:
MOF, MYST1, PP7073, Lysine acetyltransferase 8, MYST-1, MOF, hMOF, ZC2HC8
Protein Accession Number:
Q9H7Z6
Protein Gi Number:
68565938
Ncbi Gene Id Number:
84148
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
MYST1 (MYST histone acetyltransferase 1,MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone.
Background Reference 1:
Sterner, D.E., et al. Microbiol. Mol. Biol 2000 Rev. 64: 435-459.
Background Reference 2:
Neal, K.C., et al. Biochim. Biophys. 2000 Acta 1490: 170-174.
Background Reference 3:
Akhtar, A., et al. EMBO 2001 Rep. 2: 113-118.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

32-197

List Size:
0.1 mL

List Price:

$432.00

Datasheet
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