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Western blot analysis of lysed extracts from HeLa and 3T3 cells using α-Synuclein (Ab-136).
Immunofluorescence staining of methanol-fixed HeLa cells using α-Synuclein (Ab-136).
Western blot analysis of lysed extracts from HeLa and 3T3 cells using α-Synuclein (Ab-136).

a Synuclein (Ab 136) Antibody

CATALOG NUMBER: 79-604

Clonality:
Polyclonal
Tested Applications:
IF, WB
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Immunogen:
a-Synuclein (Ab-136) antibody was raised against a peptide sequence around aa. 134~138 (Q-D-Y-E-P) derived from Mouse α-Synuclein.
Conjugate:
Unconjugated
Tested Applications:
IF, WB
Application Note:
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of total α-Synuclein protein.
Predicted Molecular Weight:
18 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
Snca
Additional Names:
NACP, alphaSYN, NACP, SYN, SYUA, alpha-synuclein
Protein Accession Number:
NP_001035916.1
Protein Gi Number:
109638747
Ncbi Gene Id Number:
20617
Background:
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Background Reference 1:
Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43): 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14): 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2): 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-604

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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