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Western blot analysis of lysed extracts from HL60 cells using ABL1/2 (phospho-Tyr393/429).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ABL1/2 (Phospho-Tyr393/429).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using ABL1/2 (phospho-Tyr393/429).
Western blot analysis of lysed extracts from HL60 cells using ABL1/2 (phospho-Tyr393/429).

ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody

CATALOG NUMBER: 79-245

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
ABL1/2 (phospho-Tyr393/429) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y (p) -T-A) derived from Human ABL1/2.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429.
Predicted Molecular Weight:
210 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
ABL1 ABL2
Additional Names:
ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl, BHLHE39, Abelson murine leukemia viral oncogene homolog 1
Protein Accession Number:
NP_005148.2;NP_001129472.1
Protein Gi Number:
62362414 / 209862772
Ncbi Gene Id Number:
25;27
Background:
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Background Reference 1:
Wang, J. Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N. N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B. B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-245

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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