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Western blot analysis of extracts from COS cells treated with EGF using ABL1 (Phospho-Thr735) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from COS cells treated with EGF using ABL1 (Phospho-Thr735) Antibody. The lane on the right is treated with the antigen-specific peptide.

ABL1 (phospho Thr735) Antibody

CATALOG NUMBER: 79-839

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
ABL1 (phospho Thr735) antibody was raised against a peptide sequence around phosphorylation site of threonine735 (S-V-T (p)-L-P) derived from Human ABL1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous levels of ABL1 only when phosphorylated at threonine 735.
Predicted Molecular Weight:
135 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
ABL1
Additional Names:
Abelson murine leukemia viral oncogene 1, ABL1, c-ABL, JTK7, p150
Protein Accession Number:
NP_005148.2
Protein Gi Number:
62362414
Ncbi Gene Id Number:
25
Background:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Background Reference 1:
Fainstein E., Oncogene 4:1477-1481(1989).
Background Reference 2:
Shtivelman E., Cell 47:277-284(1986).
Background Reference 3:
Chissoe S.L., Genomics 27:67-82(1995).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-839

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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