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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis in 293 cell line lysates (35ug/lane).

ACACA Antibody

CATALOG NUMBER: 58-978

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This ACACA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2010-2039 amino acids from the C-terminal region of human ACACA.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
266 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ACACA
Additional Names:
Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA
Protein Accession Number:
Q13085
Protein Gi Number:
118601083
Ncbi Gene Id Number:
31
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Acetyl-CoA carboxylase (ACC) is a complex multifunctionalenzyme system. ACC is a biotin-containing enzyme which catalyzesthe carboxylation of acetyl-CoA to malonyl-CoA, the rate-limitingstep in fatty acid synthesis. There are two ACC forms, alpha andbeta, encoded by two different genes. ACC-alpha is highly enrichedin lipogenic tissues. The enzyme is under long term control at thetranscriptional and translational levels and under short termregulation by the phosphorylation/dephosphorylation of targetedserine residues and by allosteric transformation by citrate orpalmitoyl-CoA. Multiple alternatively spliced transcript variantsdivergent in the 5' sequence and encoding distinct isoforms havebeen found for this gene.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Background Reference 3:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 4:
Kim, C.W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9626-9631(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-978

List Size:
400 ul

List Price:

$495.00

Datasheet
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