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ACE-2 Recombinant Protein

CATALOG NUMBER: 10-014

Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln18-Ser740
Fusion Tag:
His Tag
Predicted Molecular Weight:
Mol Mass: 84.63kD; AP Mol Mass: 103kD
Biological Activity:
Human ACE2 protein can bind with SARS-CoV-2 Spike protein (RBD) in functional ELISA assay.
Purity:
>95% as determined by reducing SDS-PAGE.
physical-state:
Liquid
Buffer:
20mM Tris, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
Concentration:
batch dependent
Storage Conditions:
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.
Ncbi Official Symbol:
ACE2
Additional Names:
Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, ACE2
Protein Accession Number:
Q9BYF1
Ncbi Gene Id Number:
59272
Background:
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family which includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase and converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be highly expressed in testis, kidney, heart, colon, small intestine and ovary at moderate levels. ACE2 is not inhibited by the classical ACE inhibitors, captopril and lisinopril and may play an important role in regulating the heart function.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

10-014

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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