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Western blot analysis in mouse heart tissue lysates (35ug/lane).
Western blot analysis in mouse heart tissue lysates (35ug/lane).

ACTN2 Antibody

CATALOG NUMBER: 58-122

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This ACTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-779 amino acids from the C-terminal region of human ACTN2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
104 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ACTN2
Additional Names:
Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein, ACTN2
Protein Accession Number:
P35609
Protein Gi Number:
543742
Ncbi Gene Id Number:
88
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Alpha actinins belong to the spectrin gene superfamilywhich represents a diverse group of cytoskeletal proteins,including the alpha and beta spectrins and dystrophins. Alphaactinin is an actin-binding protein with multiple roles indifferent cell types. In nonmuscle cells, the cytoskeletal isoformis found along microfilament bundles and adherens-type junctions,where it is involved in binding actin to the membrane. In contrast,skeletal, cardiac, and smooth muscle isoforms are localized to theZ-disc and analogous dense bodies, where they help anchor themyofibrillar actin filaments. This gene encodes a muscle-specific,alpha actinin isoform that is expressed in both skeletal andcardiac muscles.
Background Reference 1:
Saus, E., et al.Psychiatr Res 44(14):971-978(2010)
Background Reference 2:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 3:
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Background Reference 4:
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-122

List Size:
400 ul

List Price:

$495.00

Datasheet
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