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Adenovirus-9 E4 Orf1 Antibody

CATALOG NUMBER: 4749

Clonality:
Polyclonal
Tested Applications:
ELISA
Host Species:
Rabbit
Species Reactivity:
Virus
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Virus
Immunogen:
Ad-9 E4 Orf1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of the Ad-9 E4 Orf1.
The immunogen is located within the last 50 amino acids of Adenovirus-9 E4 Orf1.
Conjugate:
Unconjugated
Tested Applications:
ELISA
Application Note:
Ad-9 E4 Orf1 antibody can detect 10ng Ad-9 E4 Orf1 peptide in ELISA at 1 μg/mL.
Purification:
Adenovirus-9 E4 Orf1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Adenovirus-9 E4 Orf1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Adenovirus-9 E4 Orf1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
E4
Additional Names:
Adenovirus-9 E4 Orf1 Antibody: E4-ORF1, ORF1
Protein Accession Number:
P89079
Protein Gi Number:
62510674
Ncbi Gene Id Number:
6386282
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Adenovirus-9 E4 Orf1 Antibody: The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents. Unlike the Ads from subgroup A and B, the ones from subgroup D, Ad9 and Ad10 elicit estrogen-dependent mammary tumors as opposed to undifferentiated sarcomas. In the case of Ad9, its tumorigenicity is dependent on the product of the open reading frame (ORF) 1 of the early region 4 (E4). The tumorigenic potential of Ad9 E4 Orf1 depends on a carboxyl-terminal PDZ domain-binding motif that mediates interactions with several different membrane-associated cellular proteins such as MUPP1, PATJ, MAGI-1, ZO-2 and Dlg1. It has been suggested that Ad9 E4 Orf1 may have evolved from an ancestral cellular dUTP pyrophosphatase.
Background Reference 1:
Shenk T. Adenoviridae: the viruses and their replication, p. 2265-2300 in DM Knipe and PM Howley (ed.) Fields virology, 4th ed.Vol. 2. 2001. Lippincott-Raven Publishers, Philadelphia, PA.
Background Reference 2:
Javier R, Rasha Jr. K, Macdonald GJ, et al. Human adenovirus type 9-induced rat mammary tumors. J. Virol.1991; 65:3192-202.
Background Reference 3:
Javier RT. Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats. J. Virol.1994; 68:3917-24.
Background Reference 4:
Weiss RS, Lee SS, Prasad BV, et al. Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes. 1997; J. Virol.1997; 71:1857-70.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4749

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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