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AIFM2 (IN) Peptide

CATALOG NUMBER: 9655P

Tested Applications:
Blocking
Specifications
Peptide Aa Location:
14 amino acids near the center of AIFM2 (IN).
Species:
Human
Tested Applications:
Blocking
Application Note:
AIFM2 (IN) Peptideis used for blocking the activity of theAIFM2 (IN) Antibody
physical-state:
Liquid
Buffer:
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Concentration:
200 ug/mL
Storage Conditions:
Store AIFM2 (IN) Peptide at -20°C, stable for one year.
Ncbi Official Symbol:
AIMF2
Additional Names:
AIMF2
Protein Accession Number:
Q9BRQ8
Protein Gi Number:
74752283
Ncbi Gene Id Number:
84883
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type). AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro)viral) cytosolic DNA, thus contributing to the onset of apoptosis
Background Reference 1:
Dai et al. Biochem Biophys Res Commun. 2020; 523(4):966-971
Background Reference 2:
Bersuker et al. Nature 2019; 575(7784):688-692
Background Reference 3:
Doll et al. Nature 2019; 575(7784):693-698
Background Reference 4:
Chen et al. J Mol Neurosci 2019; 68(2): 304-310
Background Reference 5:
Gong et al. J Biol Chem 2007; 282(41):30331-30340

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

9655P

List Size:
0.05 mg

List Price:

$119.00

Datasheet
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