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Western blot analysis in mouse kidney tissue lysates (35ug/lane).
Confocal immunofluorescent analysis of AIRE Antibody with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Western blot analysis in mouse kidney tissue lysates (35ug/lane).

AIRE Antibody

CATALOG NUMBER: 55-609

Clonality:
Polyclonal
Tested Applications:
IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This AIRE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human AIRE.
Conjugate:
Unconjugated
Tested Applications:
IF, WB
Application Note:
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
Predicted Molecular Weight:
58 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
AIRE
Additional Names:
Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, APECED protein, AIRE, APECED
Protein Accession Number:
O43918
Ncbi Gene Id Number:
326
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a transcriptional regulator that formsnuclear bodies and interacts with the transcriptional coactivatorCBP. At least three splice variant mRNAs products have beendescribed including one which results in a premature stop codon anda transcript predicted to be a candidate for nuclear-mediated decay(NMD). Defects in this gene cause the rare autosomal-recessivesystemic autoimmune disease termed autoimmunepolyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Background Reference 1:
Cervato, S., et al. Clin. Endocrinol. (Oxf) 73(5):630-636(2010)
Background Reference 2:
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Background Reference 3:
Conteduca, G., et al. Clin. Immunol. 136(1):96-104(2010)
Background Reference 4:
Colome, N., et al. J. Proteome Res. 9(5):2600-2609(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-609

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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