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Western blot analysis of extracts from HeLa cells treated with Hu using AIRE (Phospho-Ser156) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from HeLa cells treated with Hu using AIRE (Phospho-Ser156) Antibody. The lane on the right is treated with the antigen-specific peptide.

AIRE (phospho Ser156) Antibody

CATALOG NUMBER: 79-892

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
AIRE (phospho Ser156) antibody was raised against a peptide sequence around phosphorylation site of Serine156 P-G-S (p)-Q-L) derived from Human AIRE.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous levels of AIRE only when phosphorylated at serine 156.
Predicted Molecular Weight:
50 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
AIRE
Additional Names:
AIRE1, APECED, APS1, APSI, PGA1
Protein Accession Number:
NP_000374.1
Protein Gi Number:
4557291
Ncbi Gene Id Number:
326
Background:
The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized.
Background Reference 1:
Nagamine K., Nat. Genet. 17:393-398(1997).
Background Reference 2:
Aaltonen J., Nat. Genet. 17:399-403(1997).
Background Reference 3:
Hattori M., Nature 405:311-319(2000).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-892

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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