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Western blot analysis of Akirin1 in A549 cell lysate with Akirin1 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of Akirin1 in A549 cell lysate with Akirin1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

Akirin1 Antibody

CATALOG NUMBER: 4799

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Akirin1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of the human Akirin1.
The immunogen is located within the first 50 amino acids of Akirin1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
Akirin1 antibody can be used for detection of Akirin1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1203 - A549 Cell Lysate
Purification:
Akirin1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Akirin1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Akirin1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
AKIRIN1
Additional Names:
Akirin1 Antibody: STRF2, C1orf108, Akirin-1
Protein Accession Number:
CAI16710
Protein Gi Number:
55962136
Ncbi Gene Id Number:
79647
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Akirin1 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Background Reference 1:
Goto A, Matsushita K, Gesellchen V, et al. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat. Immunol.2008; 9:97-104.
Background Reference 2:
Beutler B and Moresco EM. Akirins versus infection. Nat. Immunol.2008; 9:7-9.
Background Reference 3:
Sutterwala FS and Flavell RA. Immunology: cascade into clarity. Nature2008; 451:254-5.
Background Reference 4:
Tanji T and Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol.2005; 26:193-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4799

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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