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Western blot analysis of Akirin2 in Human Brain tissue lysate with Akirin2 antibody at 0.5 μg/mL in (A) the absence and (B) the presence ofblocking peptide.
Western blot analysis of Akirin2 in Human Brain tissue lysate with Akirin2 antibody at 0.5 μg/mL in (A) the absence and (B) the presence ofblocking peptide.
Trial Size

Akirin2 Antibody

CATALOG NUMBER: 4805

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
Akirin2 antibody was raised against a 15 amino acid synthetic peptide near the center of the human Akirin2.
The immunogen is located within amino acids 80 - 130 of Akirin2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
Akirin2 antibody can be used for detection of Akirin2 by Western blot at 0.5 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1303 - Human Brain Tissue Lysate
Purification:
Akirin2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Akirin2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Akirin2 antibody can be stored at 4°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
AKIRIN2
Additional Names:
Akirin2 Antibody: FBI1, C6orf166, dJ486L4.2, Akirin-2
Protein Accession Number:
EAW48578
Protein Gi Number:
119568963
Ncbi Gene Id Number:
55122
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Background Reference 1:
Goto A, Matsushita K, Gesellchen V, et al. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat. Immunol.2008; 9:97-104.
Background Reference 2:
Beutler B and Moresco EM. Akirins versus infection. Nat. Immunol.2008; 9:7-9.
Background Reference 3:
Sutterwala FS and Flavell RA. Immunology: cascade into clarity. Nature2008; 451:254-5.
Background Reference 4:
Tanji T and Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol.2005; 26:193-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4805

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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