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Western blot analysis in HepG2 cell line lysates (35ug/lane).
AKR1C2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in HepG2 cell line lysates (35ug/lane).

AKR1C2 Antibody

CATALOG NUMBER: 56-299

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Monkey
Immunogen:
This AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the C-terminal region of human AKR1C2.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
37 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
AKR1C2
Additional Names:
Aldo-keto reductase family 1 member C2, 1---, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, AKR1C2, DDH2
Protein Accession Number:
P52895
Protein Gi Number:
20532374
Ncbi Gene Id Number:
1646
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a member of the aldo/keto reductasesuperfamily, which consists of more than 40 known enzymes andproteins. These enzymes catalyze the conversion of aldehydes andketones to their corresponding alcohols using NADH and/or NADPH ascofactors. The enzymes display overlapping but distinct substratespecificity. This enzyme binds bile acid with high affinity, andshows minimal 3-alpha-hydroxysteroid dehydrogenase activity. Thisgene shares high sequence identity with three other gene membersand is clustered with those three genes at chromosome 10p15-p14.
Background Reference 1:
Setlur, S.R., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):229-239(2010)
Background Reference 2:
Wang, X., et al. PLoS ONE(8), E11934 (2010) :
Background Reference 3:
Reding, K.W., et al. Am. J. Epidemiol. 170(10):1241-1249(2009)
Background Reference 4:
Cogliati, C., et al. FEBS J. 276(20):6011-6023(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-299

List Size:
400 ul

List Price:

$495.00

Datasheet
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