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Western blot analysis of Aldh3A1 in human stomach lysate with Aldh3A1 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of Aldh3A1 in human stomach lysate with Aldh3A1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

Aldh3A1 Antibody

CATALOG NUMBER: 4787

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Aldh3A1 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Aldh3A1.
The immunogen is located within the last 50 amino acids of Aldh3A1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
Aldh3A1 antibody can be used for detection of Aldh3A1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
At least two isoforms of Aldh3A1 are known to exist. This antibody is predicted to have no cross-reactivity to Aldh3A2.
Positive Control 1:
Cat. No. 1319 - Human Stomach Tissue Lysate
Purification:
Aldh3A1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Aldh3A1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Aldh3A1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ALDH3A1
Additional Names:
Aldh3A1 Antibody: ALDH3, ALDHIII, ALDH3, Aldehyde dehydrogenase, dimeric NADP-preferring
Protein Accession Number:
NP_000682
Protein Gi Number:
22907049
Ncbi Gene Id Number:
218
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Aldh3A1 Antibody: Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldh3A1 is highly expressed in stomach and even more strongly in cornea, representing between 5 to 50% of the water soluble protein fraction in mammalian corneas. It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by not only detoxification of reactive aldehydes by also through the direct absorbtion of UV energy. However, corneas from Aldh3A1-null mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may be able to compensate for the loss of Aldh3A1.
Background Reference 1:
Vasiliou V and Pappa A. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. Pharmacology2000; 61:192-8.
Background Reference 2:
Hsu LC, Chang WC, Shibuya A, et al. Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escheria coli. J. Biol. Chem.1992; 267:3030-7.
Background Reference 3:
Pappa A, Sophos NA and Vasiliou V. Corneal and Stomach expression of aldehyde dehydrogenases: from fish to mammals. Chem. Biol. Interact.2001; 130:181-91.
Background Reference 4:
Estey T, Cantore M, Weston PA, et al. Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1. J. Biol. Chem.2007; 282:4382-92.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4787

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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