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ALK (phospho Tyr1096) Antibody

CATALOG NUMBER: 79-840

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
ALK (phospho Tyr1096) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y (p)-C-F) derived from Human ALK.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of ALK only when phosphorylated at tyrosine 1096.
Predicted Molecular Weight:
176 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
Alk
Additional Names:
ALK tyrosine kinase receptor, anaplastic lymphoma kinase, anaplastic lymphoma kinase (Ki-1), CD246; EC 2.7.10.1, kinase ALK
Protein Accession Number:
NP_004295.2
Protein Gi Number:
110347475
Ncbi Gene Id Number:
238
Background:
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain.
Background Reference 1:
Morris S.W., Oncogene 14:2175-2188(1997).
Background Reference 2:
Morris S.W., Oncogene 15:2883-2883(1997).
Background Reference 3:
Iwahara T., Oncogene 14:439-449(1997).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-840

List Size:
0.1 mg

List Price:

$376.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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