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Western blot analysis of ALSFTD in HeLa cell lysate with ALSFTD antibody at 1 μg/ml.
Immunocytochemistry of ALSFTD in A-20 cells with ALSFTD antibody at 10 μg/ml.
Western blot analysis of ALSFTD in HeLa cell lysate with ALSFTD antibody at 1 μg/ml.
Trial Size

ALSFTD Antibody

CATALOG NUMBER: 8469

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
ALSFTD antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human ALSFTD.
The immunogen is located within amino acids 400 - 450 of ALSFTD.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, WB
Application Note:
ALSFTD antibody can be used for the detection of ALSFTD by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry at 10 μg/ml.
Antibody validated: Western Blot in human samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.
Specificity:
ALSFTD antibody is human, mouse and rat reactive. At least two isoforms are known to exist.
Positive Control 1:
Cat. No. 1288 - A20 Cell Lysate
Positive Control 2:
Cat. No. 17-208 - A-20 Cell Slide
Predicted Molecular Weight:
Predicted: 53 kDa
Observed: 52 kDa
Purification:
ALSFTD Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
ALSFTD Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
ALSFTD antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
ALSFTD
Additional Names:
Amyotrophic lateral sclerosis with frontotemporal dementia, chromosome 9 open reading frame 72, C9orf72
Protein Accession Number:
NP_060795
Protein Gi Number:
37039612
Ncbi Gene Id Number:
203228
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ALSFTD (C9orf72) is considered to play a role in gender determination (1). Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG (2). Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster (3,4).
Background Reference 1:
Takada LT and Sha SJ. Neuropsychiatric features of C9orf72-associated behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease. Alzheimers Res. Ther. 2012; 4:38.
Background Reference 2:
Coon EA, Whitwell JL, Parisi JE, et al. Right temporal variant frontotemporal dementia with motor neuron disease. J. Clin. Neurosci. 2012; 19:85-91.
Background Reference 3:
Snowden JS, Rollinson S, Thompson JC, et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain 2012; 135:693-708.
Background Reference 4:
Wen X, Tan W, Westergard T, et al. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron 2014; 84:1213-25.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8469

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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$35 Dry Ice Shipment fee may be required on some items.

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