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Amphiregulin Recombinant Protein

CATALOG NUMBER: 40-546

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK
Biological Activity:
Biological activity was determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/mL. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
physical-state:
Lyophilized
Storage Conditions:
The lyophilized Amphiregulin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Amphiregulin stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing Amphiregulin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
AREG
Additional Names:
AR, SDGF, CRDGF, AREGB, Amphiregulin, Colorectum cell-derived growth factor, AR
Protein Accession Number:
NP_001648.1
Protein Gi Number:
4502199
Ncbi Gene Id Number:
374
Background:
Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant human Amphiregulin is a 11.3 kDa glycoprotein consisting of 98 amino acid residues.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-546

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $199.00 through $305.00

Datasheet
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