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Amyloid-Beta 3 Antibody

CATALOG NUMBER: 39-850

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Bovine, Human, Non-Human Primate, Sheep
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Bovine, Human, Non-Human Primate, Sheep
Immunogen:
A synthetic peptide corresponding to the N-terminus 3-pyro E start point.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC, WB
Application Note:
ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing)
Purification:
Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Concentration:
batch dependent
Ncbi Official Symbol:
APP
Additional Names:
Amyloid-Beta 3-pyr E, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, A4
Protein Accession Number:
P05067
Protein Gi Number:
112927
Ncbi Gene Id Number:
351
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Pyro-glutamic acid truncated amyloid beta 3-40/42 may have a greater propensity to aggregate under physiological conditions. In addition, this pyro E modification has been implicated as the molecular species responsible for seeding larger oligomers of amyloid-β. Pyro-glutamic acid truncated amyloid beta 3-40/42’s exact involvement in the pathophysiology of Alzheimer’s disease has not been established.
Background Reference 1:
Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G, Demuth HU. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry. 2006 Oct 17;45(41):12393-9
Background Reference 2:
He W, Barrow CJ. The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. Biochemistry. 1999 Aug 17;38(33):10871-7
Background Reference 3:
Alzheimer research forum review see http://www.alzforum.org/new/detailprint.asp?id=1577
Background Reference 4:
Youssef I, Florent-Béchard S, Malaplate-Armand C, Koziel V, Bihain B, Olivier JL, Leininger-Muller B, Kriem B, Oster T, Pillot T., N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis. Neurobiology of Aging 29 (2008) 1319-1333

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

39-850

List Size:
0.05 mg

List Price:

$626.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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