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Western blot analysis of extracts from cos-7 cells (Lane 2), using Amyloid beta A4 (Phospho-Thr743/668) Antibody. The lane on the left is treated with antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain tissue using Amyloid beta A4 (phospho-Thr743/668) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence staining of methanol-fixed HeLa cells using Amyloid beta A4 (phospho-Thr743/668) Antibody.
Western blot analysis of extracts from cos-7 cells (Lane 2), using Amyloid beta A4 (Phospho-Thr743/668) Antibody. The lane on the left is treated with antigen-specific peptide.

Amyloid beta A4 (phospho Thr743/668) Antibody

CATALOG NUMBER: 79-775

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Amyloid beta A4 (phospho Thr743/668) antibody was raised against a peptide sequence around phosphorylation site of threonine 743 /668 (A-V-T (p)-P-E) derived from Human Amyloid beta A4.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity:
The antibody detects endogenous levels of Amyloid beta A4 only when phosphorylated at threonine 743/668.
Predicted Molecular Weight:
140 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
APP
Additional Names:
A4, AD1, APP, APPI, Beta-amyloid protein 42
Protein Accession Number:
NP_000475.1
Protein Gi Number:
28721
Ncbi Gene Id Number:
351
Background:
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
Background Reference 1:
Ming-Sum Lee J. Cell Biol., Oct 2003; 163: 83.
Background Reference 2:
Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006; 11: 633 - 645
Background Reference 3:
Keun-A Chang, Mol. Cell. Biol., Jun 2006; 26: 4327 – 4338.
Background Reference 4:
Thor D. Stein J. Neurosci., Sep 2004; 24: 7707 - 7717

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-775

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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