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Western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the AR antibody detected the AR protein (arrow).
Western blot analysis in Hela cell line lysates (35ug/lane).This demondetected the ANDR protein (arrow).
Androgen Receptor Antibody (ANDR) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Androgen Receptor Antibody (ANDR) for immunohistochemistry.
Western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the AR antibody detected the AR protein (arrow).

Androgen Receptor Antibody

CATALOG NUMBER: 61-403

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Monkey, Pig
Immunogen:
This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR).
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
99 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
AR
Additional Names:
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Protein Accession Number:
P10275
Protein Gi Number:
113830
Ncbi Gene Id Number:
367
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor; sumoylation of ANDR represses androgen receptor dependent transcription.
Background Reference 1:
Nishida, et al. J. Biol. Chem. 277 (44), 41311-41317 (2002)
Background Reference 2:
Sills, E.S., et al., Int. J. Mol. Med. 9(1):45-48 (2002).
Background Reference 3:
Chavez, B., et al., J. Hum. Genet. 46(10):560-565 (2001).
Background Reference 4:
Ahmed, S.F., et al., J. Clin. Endocrinol. Metab. 85(2):658-665 (2000).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

61-403

List Size:
400 ul

List Price:

$495.00

Datasheet
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