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Western blot analysis of ANGPT2 in human liver tissue lysate with ANGPT2 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of ANGPT2 in mouse liver tissue with ANGPT2 antibody at 2.5 μg/mL.
Western blot analysis of ANGPT2 in human liver tissue lysate with ANGPT2 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

ANGPT2 Antibody

CATALOG NUMBER: 6737

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (100%)
Immunogen:
ANGPT2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human ANGPT2.
The immunogen is located within the last 50 amino acids of ANGPT2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
ANGPT2 antibody can be used for detection of ANGPT2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Specificity:
At least three isoforms of ANGPT2 are known to exist; this antibody will detect all three isoforms.
Positive Control 1:
Cat. No. 1304 - Human Liver Tissue Lysate
Predicted Molecular Weight:
Predicted: 55 kDa
Observed: 58 kDa
Purification:
ANGPT2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
ANGPT2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
ANGPT2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ANGPT2
Additional Names:
ANGPT2 Antibody: ANG2, AGPT2, Angiopoietin-2, ANG-2
Protein Accession Number:
NP_001138
Protein Gi Number:
4557315
Ncbi Gene Id Number:
285
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ANGPT2 Antibody: Angiopoietin-2 (ANGPT2) is a member of the Ang family, a family of angiogenic factors that play major roles in angiogenesis during the development and growth of human cancers, but also during lymphangiogenesis. ANGPT2 is generally considered an antagonist of ANGPT1 and endothelial TEK tyrosine kinase (TIE-2, TEK). ANGPT2 disrupts the vascular remodeling ability of ANGPT1 and is thought to induce endothelial cell apoptosis, resulting in vessel regression. Expression of ANGPT2 has been linked to invasive and metastatic phenotypes of gliomas and other cancers.
Background Reference 1:
Hu B and Cheng SY. Angiopoetin-2: Development of inhibitors for cancer therapy. Curr. Oncol. Rep. 2009; 11:111-6.
Background Reference 2:
Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277:55-60.
Background Reference 3:
Lobov IB, Brooks PC, Lang RA, et al. Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc. Natl. Acad. Sci. USA 2002; 99:11205-10.
Background Reference 4:
Bach F, Uddin FJ, Burke D, et al. Angiopoietins in malignancy. Eur. J. Surg. Oncol. 2007; 33:7-15.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6737

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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