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Western blot analysis of APAF1 with an E coli-derived fusion protein as test antigen, using XW-7034 diluted 1:2,000.
Western blot analysis of APAF1 with an E coli-derived fusion protein as test antigen, using XW-7034 diluted 1:2,000.

APAF1 Antibody

CATALOG NUMBER: XW-7034

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Chicken
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Chicken
Species Reactivity:
Human, Mouse
Immunogen:
307-388
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Apaf-1 antibody can be used for the detection of Apaf-1 by Western blot, may also work for IHC and ICC.
Predicted Molecular Weight:
141.8 kDa (calculated)
Purification:
Antigen affinity-purified
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Phosphate-Buffered Saline. No preservatives added.
Concentration:
1 mg/mL
Storage Conditions:
APAF1 antibody can be stored at 4°C for short term (weeks). Long term storage should be at -20°C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
APAF1
Additional Names:
KIAA0413, Apoptotic protease-activating factor 1APAF-1, CED4, APAF-1,
Protein Accession Number:
NP_863658.1
Protein Gi Number:
32483361
Ncbi Gene Id Number:
317
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Apoptotic protease activating factor 1. Apaf-1 is a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
Background Reference 1:
Cecconi,F., Alvarez-Bolado,G., Meyer,B. I., Roth,K. A. and Gruss,P. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94 (6), 727-737 (1998),

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

XW-7034

List Size:
0.05 mg

List Price:

$638.00

Datasheet
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