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Western blot analysis in mouse heart tissue lysates (35ug/lane).
Western blot analysis in mouse heart tissue lysates (35ug/lane).

APC Antibody

CATALOG NUMBER: 60-427

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Immunogen:
This APC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the Central region of human APC.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
312 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
physical-state:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
APC
Additional Names:
Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25
Protein Accession Number:
P25054
Protein Gi Number:
97535708
Ncbi Gene Id Number:
324
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a tumor suppressor protein that acts asan antagonist of the Wnt signaling pathway. It is also involved inother processes including cell migration and adhesion,transcriptional activation, and apoptosis. Defects in this genecause familial adenomatous polyposis (FAP), an autosomal dominantpre-malignant disease that usually progresses to malignancy.Disease-associated mutations tend to be clustered in a small regiondesignated the mutation cluster region (MCR) and result in atruncated protein product.
Background Reference 1:
Chung, K.H., et al.Neurosurg Pediatr 6(4):372-376(2010)
Background Reference 2:
Rai, K., et al. Cell 142(6):930-942(2010)
Background Reference 3:
Poulogiannis, G., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15145-15150(2010)
Background Reference 4:
Jaulin, F., et al. J. Cell Biol. 190(3):443-460(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-427

List Size:
400 ul

List Price:

$495.00

Datasheet
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