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Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 μg/mL (A), 2 μg/mL (B), and 4 μg/mL (C).
Immunohistochemistry of APRIL in human prostate tissue with APRIL antibody at 10 μg/mL.
Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 μg/mL (A), 2 μg/mL (B), and 4 μg/mL (C).
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APRIL Antibody

CATALOG NUMBER: 2415

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
APRIL antibody was raised against a synthetic peptide corresponding to amino acids within a extracellular domain of human APRIL.
The immunogen is located within amino acids 180 - 230 of APRIL.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
APRIL antibody can be used for detection of APRIL by Western blot at 1 - 4 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1205 - Jurkat Cell Lysate
Positive Control 2:
Cat. No. 1312 - Human Prostate Tissue Lysate
Predicted Molecular Weight:
Predicted: 27 kDa
Observed: 27 kDa
Purification:
APRIL Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
APRIL Antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
APRIL antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TNFSF13
Additional Names:
APRIL Antibody: APRIL, CD256, TALL2, ZTNF2, TALL-2, TRDL-1, UNQ383/PRO715, APRIL, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand
Protein Accession Number:
NP_003799
Protein Gi Number:
4507599
Ncbi Gene Id Number:
8741
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1α (for TNF related death ligand 1α) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
Background Reference 1:
Hahne M, Kataoka T, Schroter M, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med. 1998; 188:1185-90.
Background Reference 2:
Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 1999; 65:680-3.
Background Reference 3:
Kelly K, Manos E, Jensen G, et al. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 2000; 60:1021-7.
Background Reference 4:
Yu G, Boone T, Delaney J, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immunol. 2000; 1:252-6.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

2415

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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