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APRIL multimeric Recombinant Protein

CATALOG NUMBER: 90-273

Specifications
source-species:
HEK293 cells
Species:
Human, Mouse
source-species:
HEK293 cells
Recombinant Protein Sequence:
The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a DDDDK-tag.
Fusion Tag:
DDDDK Tag
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
Stimulates B cell proliferation.
Purity:
>95% (SDS-PAGE).

Endotoxin level is less than 0.02EU/ μg purified protein (LAL test; Lonza).
physical-state:
Lyophilized
Buffer:
Contains PBS + 0.5% Trehalose. Reconstitute with 100 μl sterile water.
Concentration:
0.1mg/ml after reconstitution.
Storage Conditions:
Stable for at least 6 months after receipt when stored at -20°C.
Ncbi Official Symbol:
Tnfsf13
Additional Names:
ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:
Protein Accession Number:
Q9D777
Protein Gi Number:
21363035
Ncbi Gene Id Number:
69583
Background:
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-273

List Size:
10 ug

List Price:

$495.00

Datasheet
Shipping Info

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