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Human APRIL, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human BCMA, Mouse IgG2a Fc Tag, low endotoxin at 5 ug/mL (100 uL/well) can bind Human APRIL, Fc Tag with a linear range of 0.6-10 ng/mL (QC tested).
Immobilized Human APRIL, Fc Tag at 5 ug/mL (100 uL/well) can bind Biotinylated Human TACI, Fc,Avitag with a linear range of 0.01-0.313 ug/mL (Routinely tested).
Human APRIL, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

APRIL / TNFSF13 Recombinant Protein

CATALOG NUMBER: 11-421

Tested Applications:
ELISA, WB
Specifications
Source Species:
HEK293 cells
Species:
Human
Source Species:
HEK293 cells
Recombinant Protein Sequence:
Ala 105 - Leu 250
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 42.8 kDa. The protein migrates as 48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
42.8 kDa
Purity:
>95% as determined by SDS-PAGE.
Physical State:
Lyophilized
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
TNFSF13
Additional Names:
APRIL,TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2
Protein Accession Number:
NP_003799.1
Ncbi Gene Id Number:
8741
Background:
APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.
Background Reference 1:
García-Castro A, et al. 2015, Carcinogenesis., 36(5):574-84.
Background Reference 2:
Schuepbach-Mallepell S, et al. 2015, J Biol Chem., 290(26):16330-42.
Background Reference 3:
Zhi X, et al. 2015, Cell Physiol Biochem, 35(2):571-85.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-421

List Size:
0.1 mg

List Price:

$505.00

Out of stock

Datasheet
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